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Symbol
Name
ID 		Tnf
tumor necrosis factor
MGI:104798
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Increased circulating IgE level
Increased circulating IgG level
Polyclonal elevation of IgM
Decreased circulating antibody level
Increased circulating antibody level
Paraproteinemia
Leukocytosis
Leukopenia
Sinusitis
Chronic sinusitis
Allergic rhinitis
Conjunctivitis
Keratoconjunctivitis sicca
Pericarditis
Lymphadenopathy
Abnormality of the spleen
Splenic infarction
Splenic rupture
Splenomegaly
Hepatosplenomegaly
Helicobacter pylori infection
Hepatitis
Subacute progressive viral hepatitis
Pancreatitis
Uveitis
Iridocyclitis
Epididymitis
Lupus nephritis
Nephritis
Abnormality of the immune system
Recurrent cutaneous abscess formation
Acne inversa
Eczematoid dermatitis
Atopic dermatitis
Erythema nodosum
Perifolliculitis
Recurrent skin infections
Chronic furunculosis
Discoid lupus rash
Malar rash
Osteomyelitis
Recurrent pneumonia
Serositis
Decreased circulating complement C3 concentration
Decreased circulating complement C4 concentration
Autoimmunity
Anti-citrullinated protein antibody positivity
Antineutrophil antibody positivity
Perinuclear antineutrophil antibody positivity
Antinuclear antibody positivity
Anti-dsDNA antibody positivity
Anti-La/SS-B antibody positivity
Anti-Sm antibody positivity
Anti-U1 ribonucleoprotein antibody positivity
Antiphospholipid antibody positivity
Rheumatoid factor positive
Systemic lupus erythematosus
Asthma
Nontuberculous mycobacterial pulmonary infection
Recurrent Burkholderia cepacia infections
Recurrent Haemophilus influenzae infections
Recurrent Staphylococcus aureus infections
Recurrent Aspergillus infections
Recurrent respiratory infections
Recurrent bronchopulmonary infections
Recurrent lower respiratory tract infections
Disease(s) Associated with TNF
asthma
atopic dermatitis
Behcet's disease
beta thalassemia
cystic fibrosis
Gaucher's disease
hepatocellular carcinoma
hidradenitis suppurativa
hypochromic microcytic anemia
leprosy
multiple myeloma
pre-eclampsia
rheumatoid arthritis
Sjogren's syndrome
systemic lupus erythematosus
thrombocytopenia
type 1 diabetes mellitus

Mouse Phenotypes
immune system phenotype
cardiovalvulitis
aortic valve inflammation
mitral valve inflammation
myocarditis
impaired macrophage phagocytosis
accelerated temporomandibular joint osteoarthritis
intestinal inflammation
large intestinal inflammation
colitis
small intestinal inflammation
ileum inflammation
esophageal inflammation
thymus hypoplasia
insulitis
enlarged spleen
increased spleen weight
abnormal class switch recombination
abnormal myelopoiesis
increased neutrophil cell number
increased dendritic cell number
absent germinal center B cells
increased B cell number
abnormal T cell subpopulation ratio
increased CD4-positive, alpha-beta memory T cell number
increased CD4-positive, alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
increased CD8-positive, alpha-beta T cell number
decreased T cell number
increased lymphocyte cell number
increased leukocyte cell number
abnormal dendritic cell morphology
abnormal B cell morphology
abnormal T cell morphology
abnormal CD4-positive, alpha beta T cell morphology
abnormal CD8-positive, alpha beta T cell morphology
abnormal alpha-beta intraepithelial T cell morphology
abnormal gamma-delta T cell morphology
abnormal metallophilic macrophage morphology
abnormal microglial cell morphology
abnormal spleen morphology
intermingled spleen red and white pulp
abnormal spleen white pulp morphology
abnormal spleen B cell follicle morphology
decreased spleen B cell follicle number
abnormal spleen follicular dendritic cell network
abnormal spleen primary B follicle morphology
absent spleen germinal center
decreased spleen germinal center number
decreased spleen germinal center size
abnormal spleen marginal sinus morphology
abnormal spleen marginal zone morphology
absent spleen marginal zone
decreased spleen white pulp amount
abnormal neutrophil physiology
abnormal lymphocyte physiology
decreased IgA level
decreased IgG1 level
decreased IgG2a level
decreased IgG3 level
decreased IgG level
increased IgM level
decreased immunoglobulin level
abnormal T cell physiology
abnormal CD4-positive, alpha-beta T cell physiology
abnormal T-helper 17 cell physiology
abnormal cytotoxic T cell physiology
abnormal macrophage physiology
decreased macrophage cytokine production
abnormal circulating chemokine level
decreased circulating interferon-gamma level
decreased circulating interleukin-1 alpha level
decreased circulating interleukin-1 beta level
decreased circulating interleukin-6 level
decreased circulating tumor necrosis factor level
increased circulating tumor necrosis factor level
abnormal cytokine level
decreased follicular dendritic cell number
absent follicular dendritic cells
abnormal bronchus-associated lymphoid tissue morphology
abnormal Peyer's patch morphology
abnormal Peyer's patch follicle morphology
abnormal Peyer's patch T cell area morphology
abnormal Peyer's patch germinal center morphology
decreased Peyer's patch number
small Peyer's patches
absent Peyer's patches
abnormal mesenteric lymph node morphology
absent mesenteric lymph nodes
abnormal lymph node cell ratio
abnormal lymph node B cell domain morphology
abnormal lymph node primary follicle morphology
absent lymph node germinal center
lymph node hypoplasia
absent axillary lymph nodes
absent brachial lymph nodes
absent cervical lymph nodes
absent inguinal lymph nodes
absent popliteal lymph nodes
absent peripheral lymph nodes
absent lymph nodes
abnormal immune system physiology
decreased susceptibility to type IV hypersensitivity reaction
abnormal humoral immune response
abnormal follicular dendritic cell physiology
abnormal cytokine secretion
abnormal chemokine secretion
decreased interferon-gamma secretion
increased interferon-gamma secretion
increased interleukin-2 secretion
decreased tumor necrosis factor secretion
increased tumor necrosis factor secretion
autoimmune response
decreased susceptibility to autoimmune disorder
decreased susceptibility to experimental autoimmune encephalomyelitis
decreased susceptibility to induced arthritis
rheumatoid arthritis
abnormal inflammatory response
decreased susceptibility to endotoxin shock
increased susceptibility to endotoxin shock
chronic inflammation
chronic liver inflammation
decreased inflammatory response
brain inflammation
arthritis
kidney inflammation
lung inflammation
alveolitis
interstitial pneumonia
skin inflammation
abnormal susceptibility to infection
decreased susceptibility to bacterial infection
increased susceptibility to bacterial infection
increased susceptibility to bacterial infection induced morbidity/mortality
increased susceptibility to fungal infection
decreased susceptibility to parasitic infection
increased susceptibility to parasitic infection
increased susceptibility to Poxviridae infection
increased susceptibility to Riboviria infection
abnormal response to transplant
Availability Mouse Genotype
Lta/Tnftm1Eug/Lta/Tnftm1Eug
Lta/Tnftm1Fda/Lta/Tnftm1Fda
Lta/Tnftm1Jods/Lta/Tnftm1Jods
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
TnfBpsm1/TnfBpsm1
TnfM1Btlr/TnfM1Btlr *
TnfR8H/TnfR8H
Tnftm1.2Sned/Tnftm1.2Sned
Tnftm1Gkl/Tnftm1Gkl *
Tnftm1Jods/Tnftm1Jods
Tnftm1Ljo/Tnftm1Ljo
Tnftm1Sek/Tnftm1Sek *
Tnftm2Gkl/Tnftm2Gkl
Tnftm2Jods/Tnftm2Jods *
Tnftm3Gkl/Tnftm3Gkl
Lta/Tnftm1Fda/Tnf+
TnfBpsm1/Tnf+
Tnfem4Boui/Tnf+
TnfM1Btlr/Tnf+ *
TnfM2Btlr/Tnf+
Tnftm1Gkl/Tnftm2Gkl
Tnftm1Ljo/Tnf+
Tnftm2Gkl/Tnf+ !
Tg(Ins2-Tnf)17Flv/0 *
Tg(SFTPC-rtTA,tetO-Tnf)320-1Gwho/0
Tg(SFTPC-Tnf)2Pva/0
Tg(Tek-Tnf*)5382Mcla/0
Tg(Tnf)6074Gkl/0
Tg(Myh6-Tnf)1Brgi/?
Tg(Myh6-Tnf)2Brgi/?
Tnftm1.1Sned/Tnftm1.1Sned
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)
Tnftm1.1Sned/Tnftm1.1Sned
Tg(Cd4-cre)1Cwi/0  (conditional)
Tnftm1.1Sned/Tnftm1.1Sned
Cd19tm1(cre)Cgn/Cd19+  (conditional)		 *
Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Lck-cre)I57Jxm/0  (conditional)
Cd19tm1(cre)Cgn/Cd19+
Tnftm2.1Gkl/Tnftm2.1Gkl  (conditional)		 *
Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Fabp1-cre)1Jig/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory